I have a patient with anaphylactic (urticaria, angioedema and hypotension affecting renal function reversed after hydration) reaction a few hours after taking Aleve. No other etiology can be found to cause the symptoms or reaction. Consulting MD wanted testing but from the recent practice parameter I read, there seems to be no skin testing method that we can use (correct me if I am wrong) other than oral challenge with the same drug (it can be drug specific). But this comes with a very high risk of having the same life threatening symptoms or event. If there is a test, please help provide protocol.