I have a patient who has CVID and is doing well on IVIG. He has osteoporosis and his endocrinologist wants to start him on denosumab which is a monoclonal antibody towards RANK ligand. There is no contraindications listed in the package inserts for taking IVIG and denosumab concomitantly. I have contacted the companies but am waiting to hear back. However I wanted to see from experts in the field of IVIG/immunodeficiency if there is any contraindication in receiving IVIG along with a monoclonal antibody?


Thank you for your inquiry.

I can see no reason to be concerned about the simultaneous administration of a monoclonal antibody to a patient who has common variable immunodeficiency and is receiving immunoglobulin replacement; nor can I see any contraindication specifically regarding the use of denosumab in this context.

Thank you again for your inquiry and we hope this response is helpful to you.

Phil Lieberman, M.D.

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