My practice is trying to downsize (or at least revise) its inhalant allergen skin testing panel. When writing immunotherapy prescriptions, I often select the minimum number of cross-reactive allergens for treatment. For example, if a patient is sensitive to multiple Northern grasses, I might just add Timothy grass to the treatment vial. Do similar relationships hold for testing? For example, if the cross-reactive allergens Yellow Dock and Sheep Sorrel are native to our area, would it be OK to simply test for Sheep Sorrel and hope that it picks up Dock-sensitive patients? I suspect cutting down on the number of cross-reactive allergens would decrease the sensitivity of our skin testing, but I am not sure if this would be significant enough to keep excess allergens on hand for treatment and testing.