Thank you for your inquiry.
I am not aware of any relationship between gastroesophageal reflux and recurrent episodes of angioedema of the face. Also, I could not find any such relationship using an Internet search. I would mention however, parenthetically, that if angioedema involves the face, it may also of course involve the esophagus. Although I have not seen pain and discomfort associated with esophageal angioedema being misinterpreted as esophageal reflux, theoretically I believe this could occur.
So, the only theoretical relationship that crosses my mind would be related to the possibility that esophageal angioedema is occurring in your patient, along with the facial angioedema, and that it may be misinterpreted as reflux or perhaps aggravating reflux.
Thank you again for your inquiry and we hope this response is helpful to you.
Phil Lieberman, M.D.