I was wondering if there were any known contraindications to allergy shots in a patient with mild focal segmental glomerular sclerosis and mild/stable nephrotic syndrome.


Thank you for your inquiry.

There is no specific contraindication to the administration of allergen immunotherapy to a patient with focal segmental glomerulosclerosis and mild stable nephrotic syndrome. However there are theoretical considerations which give some pause.One is that immunizations might produce immune complexes which could theoretically be a problem. And the other question is of whether or not this disease might diminish the likelihood of surviving an anaphylactic reaction to an allergy injection.

Thus, there is no absolute contraindication that would prohibit the administration of allergy injections to a patient with this disorder. But the clinician administering the injection therapy should take these potential problems into consideration and make a personal calculation of the risk/benefit ratio, engaging the patient in the decision, as to whether he/she feels that the potential benefit outweighs any theoretical risk.

Thank you again for your inquiry and we hope this response is helpful to you.

Phil Lieberman, M.D.

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