Q:

1/13/2013
Is there a difference in the efficacy between dosing Amb a 24 microgram once in four weeks vs 6 micrograms every week or 12 micrograms every two weeks? Patient is getting same total does over twelve months period. Thanks.

A:

Thank you for your inquiry.

I know of no studies that have looked specifically at this issue, but we do know that the most important variable in regards to the efficacy of immunotherapy in general is thought to be the total dose administered (not the frequency of dosing). Therefore I don't feel there would be any difference in efficacy between the dosage regimens you described.

Thank you again for your inquiry and we hope this response is helpful to you.

Sincerely,
Phil Lieberman, M.D.

AAAAI - American Academy of Allergy Asthma & Immunology