11/9/2012
61 yo patient who is status post liver transplant on cellcept and prednisone. Stable. No signs of organ rejection. Patient requesting to start traditional IT for refractory sinus disease and extensive allergic sensitivity. I read your responses on the efficacy of IT while on cellcept and prednisone. Is there any concern for danger to transplant patients of inducing an acute rejection of the organ in question given the T-cell proliferative response with SCIT? Thank you!

Thank you for your inquiry.

Unfortunately I am not going to be able to give you an “evidence-based” answer to this question because I could find nothing in the literature which has dealt with the issue of the effect of allergen immunotherapy on solid organ transplant survival. Thus, the only answer I could give you would be based on theoretical grounds.

Considering the known immunologic effects of allergen immunotherapy, I cannot personally see how it could increase the chances of transplant rejection. However, once again, this response is based on theoretical considerations.

Thank you again for your inquiry and we hope this response is helpful to you.

Sincerely,
Phil Lieberman, M.D.