Q:

1/13/2013
Is there a protocol for provocative dose testing to Warfarin (Coumadin)?

A:

Thank you for your inquiry.

I am not aware of nor could I find a provocative dosage regimen to warfarin. However, there is a published desensitization protocol which could serve the same purpose. The reference is copied for you below.

Thank you again for your inquiry and we hope this response is helpful to you.

Induction of Tolerance to Warfarin after Anaphylaxis with a Desensitization Protocol. Travis Jameson, Dareen Siri. Cardiology 2010;115:174-175 (DOI: 10.1159/000275922).

Sincerely,
Phil Lieberman, M.D.

AAAAI - American Academy of Allergy Asthma & Immunology