Thank you for your inquiry.
Unfortunately, I am not aware of and could not find with a literature search any “slow desensitization” protocol for desensitization to piperacillin/tazobactam. There are, however, two published protocols for a more rapid desensitization. I have copied the links for both below.
One of these appears on “Scribd.com.” It is the method suggested by Dr. Timothy Sullivan. There is, however, a small fee to download this regimen.
The other is written by Dr. Mariana Castells at Harvard Medical School. It is a protocol used for more rapid desensitization to antibiotics in general, and she has desensitized three patients to piperacillin/tazobactam using this paradigm.
In the absence of a “slow desensitization regimen,” one can simply alter the time interval between the doses suggested using either of these more rapid protocols.
Thank you again for your inquiry and we hope this response is helpful to you.
Phil Lieberman, M.D.