If a patient has documented cold induced urticaria and anaphylaxis should care be taken not to administer too cold intravenous fluids for fear of a reaction? Thank you for your advice and help.


Thank you for your inquiry.

Yes, the infusion of cold intravenous fluids can produce cold urticaria in patients with this disorder (1, 2).

Thank you again for your inquiry and we hope this response is helpful to you.

1. Lockhart CH, Brownrigg JC. Anesthetic hazards of cold urticaria. Anesthesiology 1973; 38: 96–97.
2. De la Borbolla JM, Tapies S, Mbongo C, Lafuente A, Gastaminza G. Cold urticaria: its importance in the operating room. J Investig Allergol Clin Immunol 2010; 20: 446–447.

Phil Lieberman, M.D.

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