Q:

3/22/2013
52 yo female with CVID, s/p appendectomy for chronic appendicitis. Found to be malignant (?mucocoele). Removed successfully and totally. Still with abdominal pain. GI Oncologist wants above data before he will see her. Thanks.

A:

Thank you for your inquiry.

There are two excellent reviews of common variable immunodeficiency patients, both of which cite varieties of cancers and give their incidence in their series, which would be very helpful to you. I think this would be especially true regarding the excellent review written by Dr. Charlotte Cunningham-Rundles. Both of these articles are available to you at no charge online. I have copied below the references and the links to the websites which will allow you to access them. In addition, there is a cancer registry for primary immunodeficiency diseases. This registry of course is not limited to common variable immunodeficiency disorders, but contains cancers reported in association with other immunodeficiencies. The abstract below describes this registry. You would have to order this from your medical library if you do not subscribe to the journal.

Thank you again for your inquiry and we hope this response is helpful to you.

Cancer risk among patients with IgA deficiency or common variable immunodeficiency and their relatives: a combined Danish and Swedish study. Clin Exp Immunol. 2002 December; 130(3): 495–500.

Charlotte Cunningham-Rundles:
Blood 2010; 116(1) 7-15

Am J Pediatr Hematol Oncol. 1987 Summer;9(2):183-4.
The Immunodeficiency Cancer Registry. A research resource.
Filipovich AH, Heinitz KJ, Robison LL, Frizzera G.
Abstract
The Immunodeficiency Cancer Registry (ICR) contains nearly 500 case records regarding patients with primary immunodeficiencies who have developed malignancies. There is a proportional excess of lymphomas (50.7%) among the ICR cases and more than one-half of these cases were diagnosed at less than 10 years of age. Information in the ICR database is accessible to investigators conducting research on the biology or epidemiology of cancers associated with immunodeficiency.

Sincerely,
Phil Lieberman, M.D.

AAAAI - American Academy of Allergy Asthma & Immunology