Q:

6/4/2014
I have a 66 year-old female patient who is on Lisinopril for a long period of time. She needs allergy skin testing. Is this a contraindication for percutaneous skin testing?

A:

Thank you for your inquiry.

There is no contraindication to percutaneous skin testing when a patient is taking an angiotensin-converting enzyme (ACE) inhibitor. I might add parenthetically, from a theoretical standpoint, because these drugs prevent the catabolism of kinins, the skin test sensitivity might be enhanced, but there is no evidence of any increased risk for side effects.

Thank you again for your inquiry and we hope this response is helpful to you.

Sincerely,
Phil Lieberman, M.D.

Allergen immunotherapy on an angiotensin-converting enzyme (ACE) inhibitor

Question:
This is an addendum to my previous submission today regarding a patient who is on Lisinopril. I also was wondering: Can this patient receive immunotherapy while on Lisinopril if indicated?

Answer:
Thank you for your inquiry.

I am presuming you are speaking of allergen immunotherapy and not venom immunotherapy. There is no contraindication to the administration of allergen immunotherapy to a patient taking an angiotensin-converting enzyme (ACE) inhibitor.

However, there is a warning in the package insert of venom immunotherapy extracts regarding the simultaneous administration of an ACE inhibitor.

Thank you again for your inquiry and we hope this response is helpful to you.

Sincerely,
Phil Lieberman, M.D.

AAAAI - American Academy of Allergy Asthma & Immunology