Thank you for your recent inquiry.
Kidney manifestations are not normally seen in Lymes disease. They are certainly not a typical component of the manifestations of Lyme’s. For your convenience, there is a reference copied below (1), which is an easily accessible excellent source of information on Lyme disease. Renal manifestations are not listed as a component of the manifesttions in patients suffering from Lyme’s.
Theoretically, however, renal disease can occur in Lyme’s disease patients who also have, as part of the disease, the antiphospholipid antibody syndrome (2) since renal manifestations can be part of the antiphospholipid antibody syndrome. For your convenience, I have copied an abstract discussing antiphospholipid antibody syndrome related to infectious diseases.
Thank you again for your inquiry and we hope this response is helpful to you.
1. eMedicine Specialties > Neurology > Neurological Infections
Author: Augusto A Miravalle, MD, Fellow, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School
Coauthor(s): R Philip Kinkel, MD, FAAN, Associate Professor of Neurology, Harvard Medical School; Director, Multiple Sclerosis Center, Beth Israel Deaconess Medical Center; Consultant Neurologist, Children's Hospital of Boston
Contributor Information and Disclosures
Updated: Jul 23, 2009
2. Clin Exp Rheumatol. 2008 Jan-Feb;26(1 Suppl 48):S12-7.
Bacterial triggers and autoimmune rheumatic diseases.
Girschick HJ, Guilherme L, Inman RD, Latsch K, Rihl M, Sherer Y, Shoenfeld Y, Zeidler H, Arienti S, Doria A.
Pediatric Rheumatology, Immunology, Infectious Diseases, Children's Hospital, University of Wuerzburg, Germany.
Autoimmune rheumatic diseases are generally considered as a multifactorial aetiology, mainly genetic susceptibility combined with environmental triggers of which bacteria are considered one of the most prominent. Among the rheumatic diseases where bacterial agents are more clearly involved as triggers are: reactive arthritis (ReA), rheumatic fever (RF) and Lyme disease. The role of bacterial infections in inducing other seronegative spondyloarthritis and antiphospholipid antibody syndrome has been hypothesized but is still not proven. The classic form of ReA is associated with the presence of HLA-B27 and is triggered by the urethritis or enteritis causing pathogens Chlamydia trachomatis and the enterobacteria Salmonella, Shigella, and Yersinia, respectively. But several other pathogens such as Brucella, Leptospira, Mycobacteria, Neisseria, Staphylococcus and Streptococcus have also been reported to cause ReA. RF is due to an autoimmune reaction triggered by an untreated throat infection by Streptococcus pyogenes in susceptible individuals. Carditis is the most serious manifestation of RF and HLA-DR7 is predominantly observed in the development of valvular lesions. Lyme disease is a tick-transmitted disease caused by the spirochete Borrelia burgdorferi. Knowledge is limited about how this spirochete interacts with human tissues and cells. Some data report that Borrelia burgdorferi can manipulate resident cells towards a pro- but also anti-inflammatory reaction and persist over a long period of time inside the human body or even inside human cells.
Phil Lieberman, M.D.
Key Words: Lyme disease, kidney disease