I have a 30 year-old man with severe chronic, apparently autoimmune, urticaria poorly responsive to high dose antihistamine therapy and would like to start him on omalizumab. He has IgA nephropathy. His nephrologist is checking with her consultants regarding possible contraindications. I know this is a rare conjunction of problems, but do you have any thoughts on possible complications in this situation?


Thank you for your inquiry.

I personally do not feel that IgA nephropathy would be a contraindication to the administration of omalizumab, and could find no help in formulating any further opinion in this regard via a literature search. So the best one can offer is a personal opinion based only on theoretical considerations. In this regard I cannot see any reason for your patient not to receive omalizumab. But I can't give you any evidence to base this decision on since I could find nothing dealing with this issue on a literature search.

Thank you again for your inquiry and we hope this response is helpful to you.

Phil Lieberman, M.D.

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