|
 |
  |
 |
 |
|
 |
|
 |
|
 |
|
 |
|
 |
|
 |
|
 |
|
 |
|
|
AND THE ANSWERS ARE . . . The correct answer is: Comment: These findings have been interpreted by some to indicate that the eosinophil may be more important in airway remodeling than in the production of symptoms of asthma. Reference: |
AND THE ANSWERS ARE . . .
The correct answer is:
A (a decline in sputum eosinophils), B (a decline in circulating eosinophils), and E (A diminution in the deposition of glycoproteins beneath the subepithelial basement membrane.Comment:
Anti-IgE dramatically reduces both circulating and sputum eosinophils. This occurs both in asthma and in hypereosinophilic syndrome as discussed previously in this column. Despite this effect on eosinophils, anti-IgE has not been shown to improve baseline airway function or produce an amelioration of the late phase reaction in the lung or skin. However, the administration of anti-IL 5 does cause a decrease in the expression of glycoproteins in the subepithelial basement membrane. These include tenascin , lumican, and procollagen 3.These findings have been interpreted by some to indicate that the eosinophil may be more important in airway remodeling than in the production of symptoms of asthma.
Reference:
Holgate ST. Pathogenesis of asthma. Clinical and Experimental Allergy 2008; 38:872-897.