|
November 2007 QUIZ OF THE MONTH . . .
Probiotics have been shown to modulate immune responses. Their administration has been associated with all of the following activities WITH THE EXCEPTION OF:
- Reduction in interleukin-10 expression.
- Induction of regulatory T cells.
- Increase in interferon-gamma expression.
- Modulate dendritic cell function.
Discussion
Probiotics such as lactobacillus rhamnosus GG have been shown to alter immunologic activity by skewing the immune response toward TH-1 rather than TH-2 activity.
All of the above effects have been shown to occur in various experimental studies employing probiotics with the exception of a reduction in inteleuukin-10. Interleukin-10 activity is increased. Interleukin-10 activity is usually associated with a decrease in TH-2 mediated pathological responses, tending to cause tolerance to antigens producing IgE-mediated hypersensitivity reactions.
References
1. Pessi, et al. Interleukin-10 generation in atopic children following oral lactobacillus rhamnosus GG. Clin Exp Allergy 2000; 30(12):1804-1808.
2. Pohjavuori E, et al. Lactobacillus GG effect in increasing interferon-gamma production in infants with cow milk allergy. J Allergy Clin Immunol 2004; 114(1):131-136.
3. Rautava S, et al. Probiotics during pregnancy and breast-feeding might confer immunomodulatory protection against atopic disease in the infant. J Allergy Clin Immunol 2002; 109(1):119-121."
Think you have the answers?
Click here to find out if you're right!
Please tell us what you think of this site.
|
