September 2006 QUIZ OF THE MONTH . . .
Suspected allergy to penicillin group and other beta-lactam antibiotics is still a major clinical problem, sometimes restricting choices of antibiotic usage. Which of the statements about this matter are true or false?
- The large majority of patients giving histories of being allergic to penicillin antibiotics do not have allergic reactions when challenged with a penicillin agent.
- A negative response in a penicilloyl poly lysine (PPL, Pre-Pen) skin test does not rule out the presence of current penicillin allergy.
- The RAST detecting IgE anti-penicilloyl antibodies is more sensitive than the PPL skin test in detecting current penicillin allergy.
- Allergic reactions to amoxicillin do not involve the beta-lactam ring structure.
- Some allergic reactions to cephalosporins are directed against drug-specific side chains.
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