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April 2006 QUIZ OF THE MONTH . . .

Ciclesonide (Cic) is a recently developed inhaled corticosteroid (ICS) agent now under extensive evaluation in the treatment of persistent asthma. Which of the statements below about Cic are true or false?

  1. Treatment with Cic in high doses affects the hypothalamic-pituitary adrenal (HPA) axis function significantly less commonly than do other ICS agents used in similar doses
  2. Cic treatment is associated with a significant incidence of oral candidiasis
  3. Cic cannot be used in combination with an inhaled long-acting beta agonist (LABA).
  4. Cic metabolite is very highly bound to plasma proteins after systemic absorption
  5. Cic must be administered by a power nebulizer

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