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NOVEMBER 2003 QUIZ OF THE MONTH . . .

Case Description
Your asthmatic patient has asked you about possible systemic effects of chronic treatment with inhaled corticosteroids (ICS). Which of the statements about ICS listed below are true?

  1. The systemic levels of currently used ICS agents are due mainly to the ICS which is swallowed and absorbed through the G-I tract.

  2. Most of the ICS which binds to systemic tissues is bound to plasma proteins.

  3. The incidence of systemic adverse effects is inversely related to the clearance rate of the ICS.

  4. Chronic therapy of asthmatic children with usual therapeutic doses of ICS results in a transient reduction in growth velocity.

  5. ICS in solution form propelled with the HFA-134 propellant are dispersed more peripherally in the lower airways than are ICS propelled with the older CFC propellant.

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