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5/21/2008 Corticosteroids Do Not Diminish Leukotriene Synthesis In Vitro, and Do Not Decrease Cysteinyl Leukotriene Receptor 1 ExpressionSummary Reference
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SELECTED ARTICLES FROM THE RECENT LITERATURE 20085/21/2008
Corticosteroids Do Not Diminish Leukotriene Synthesis In Vitro, and Do Not Decrease Cysteinyl Leukotriene Receptor 1 Expression
Summary
The investigators looked at the effect of fluticasone on the synthesis of mRNA for LTC4 synthase and the expression of the cysteinyl leukotriene receptors 1 and 2 within T lymphocytes, monocytes, and eosinophils. Although fluticasone inhibited basal cysteinyl leukotriene 2 receptor transcript expression in monocytes, and IL-4 induced expression in all three cell types, the synthesis and release of cysteinyl leukotrienes was not affected. In addition, cysteinyl leukotriene receptor 1 expression was unaltered. Since the leukoteriene receptor 2 may be assoiated with fibrblast activation they postulated that corticoteroids may modify remodelling via this mechanism.Reference
Negri J, et al. Corticosteroids as inhibitors of cysteinyl leukotriene metabolic and signaling pathways. J Allergy Clin Immunol 2008; 121(5):1232-1237.
