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SELECTED ARTICLES FROM THE RECENT LITERATURE 2008
9/15/2008
Airway pathology is similar in atopic children who wheeze and nonatopic wheezing children
Summary
The investigators of this study desired to see whether airway pathology in atopic children who wheeze is similar to or different than that of nonatopic child wheezers. They did so by performing bronchial biopsies from 55 children including 18 nonatopics with multitrigger wheeze, 20 atopic children with multitrigger wheeze, and 17 control children who were neither atopic nor had wheeze.
There was no difference between atopic and nonatopic children in biopsy findings. Both, compared to normal controls, had increased epithelial loss, thickened basement membrane, increased number of vessels, and eosinophils. In addition, both groups had increased cytokine expression highly significant for IL-4 and marginal for IL-5.
The authors concluded that the airway pathology was similar in atopic and nonatopic wheezing children.
Reference
Turato G, et al. Nonatopic children with multitrigger wheezing have airway pathology comparable to atopic asthma. American Journal of Respiratory and Critical Care Medicine 2008; 178:476-482.
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