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10/9/07 Assessment in clinical interpretation of reduced IgG valuesSummary Reference
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SELECTED ARTICLES FROM THE RECENT LITERATURE 200710/9/07
Assessment in clinical interpretation of reduced IgG values
Summary
The authors studied hypogammaglobulinemia in children under 2 years of age. Thirty-four patients were evaluated and 10 of these were found to be atopic. In 5 of the 10 patients, a diagnosis of cow's milk allergy was confirmed by skin test and/or in vitro testing. These 5 patients were treated with replacement of milk using infant formula containing hydrolyzed proteins. This therapy resulted in restoration of normal immunoglobulin values and resolution of gastrointestinal symptoms. The authors alert us to the fact that hypogammaglobulinemia during early childhood can be secondary to IgE-mediated cow's milk allergy. All of these children showed increased gastrointestinal clearance of alpha-1 antitrypsin, thus suggesting that the hypogammaglobulinemia resulted from enzyme-link via the inflamed gastrointestinal mucosa.Reference
Bezrodnik A, Raccio A, Canil L, et al., Immunology 2007; 122:140-146
