11/14/03 Fexofenadine does not affect cognitive functionSummaryIn previous studies, fexofenadine (Fex), trade name Allegra, was shown to have no significant adverse effect on driving capacity while diphenhydramine (Benadryl) significantly impaired driving capacity. The Fex dose utilized in that study was 60 mg., the standard adult dose at that time. In this current study, Potter et al compared the effects of Fex 180 mg once daily (the most common current dose) and placebo on driving and psychomotor skills in adults. They found no significant difference in the results of such tests after Fex vs placebo administration. The authors postulated that individuals with prominent allergic rhinitis (AR) might actually perform psychomotor skill tests better after Fex treatment because of a reduction in AR manifestations. Uncontrolled AR itself can impair such cognitive functions. Reference Annals of Allergy, Asthma, Immunol 2003; 91:177-81 Editor's Comments These findings are quite encouraging for those using Fex in current 180 mg once daily dosing. Actually, even higher doses of Fex have been thought to have no adverse effect on cognitive function. These findings make a strong case for the use of Fex in the treatment of allergies, especially in those in whom impairment of cognitive function/driving capacity would be particularly undesirable. In comparison, most studies have shown that sedative effects occur in 8-14% of subjects taking the usual 10 mg/day dose of cetirizine (Zyrtec). Therefore, one has to alert patients for whom cetirizine is prescribed about this possibility.
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